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      Prevalence of anxiety in the COVID-19 pandemic: An updated meta-analysis of community-based studies

      research-article
      a , b , c , a , * , d , e , f , b , c , g , b , c , c , e
      Progress in Neuro-Psychopharmacology & Biological Psychiatry
      Published by Elsevier Inc.
      Anxiety, COVID-19, Prevalence, Community-based studies, Meta-analysis, COVID-19, coronavirus infectious disease 2019, SARS-CoV-1, severe acute respiratory syndrome coronavirus 1, MERS-CoV, Middle East respiratory syndrome coronavirus, GAD, Generalized Anxiety Disorder scale, DASS, Depression Anxiety and Stress Scale, SAS, Zung Self-rating Anxiety Scale, STAI, State-Trait Anxiety Inventory, BAI, Beck Anxiety Inventory, HADS, Anxiety and Depression Scale, BSI-53, Brief Symptom Inventory-53

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          Abstract

          Background

          The unprecedented worldwide crisis caused by the rapid spread of COVID-19 and the restrictive public health measures enforced by some countries to slow down its transmission have severely threatened the physical and mental wellbeing of communities globally.

          Methods

          We conducted a systematic review and meta-analysis to determine the prevalence of anxiety in the general population during the COVID-19 pandemic. Two researchers independently searched for cross-sectional community-based studies published between December 1, 2019 and August 23, 2020, using PubMed, WoS, Embase, and other sources (e.g., grey literature, manual search).

          Results

          Of 3049 records retrieved, 43 studies were included. These studies yielded an estimated overall prevalence of anxiety of 25%, which varied significantly across the different tools used to measure anxiety. Consistently reported risk factors for the development of anxiety included initial or peak phase of the outbreak, female sex, younger age, marriage, social isolation, unemployment and student status, financial hardship, low educational level, insufficient knowledge of COVID-19, epidemiological or clinical risk of disease and some lifestyle and personality variables.

          Conclusions

          As the overall global prevalence of anxiety disorders is estimated to be 7.3% normally, our results suggest that rates of anxiety in the general population could be more than 3 times higher during the COVID-19 pandemic. These findings suggest a substantial impact on mental health that should be targeted by individual and population-level strategies.

          Highlights

          • Anxiety in the general population has increased 3-fold during the COVID-19 outbreak.

          • Anxiety appears to be highest at the initial phase and the peak of the epidemic.

          • Several risk factors have been identified.

          • Preventive and therapeutic strategies should be implemented.

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          Most cited references84

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          Measuring inconsistency in meta-analyses.

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            Bias in meta-analysis detected by a simple, graphical test

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              Is Open Access

              Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China

              Background: The 2019 coronavirus disease (COVID-19) epidemic is a public health emergency of international concern and poses a challenge to psychological resilience. Research data are needed to develop evidence-driven strategies to reduce adverse psychological impacts and psychiatric symptoms during the epidemic. The aim of this study was to survey the general public in China to better understand their levels of psychological impact, anxiety, depression, and stress during the initial stage of the COVID-19 outbreak. The data will be used for future reference. Methods: From 31 January to 2 February 2020, we conducted an online survey using snowball sampling techniques. The online survey collected information on demographic data, physical symptoms in the past 14 days, contact history with COVID-19, knowledge and concerns about COVID-19, precautionary measures against COVID-19, and additional information required with respect to COVID-19. Psychological impact was assessed by the Impact of Event Scale-Revised (IES-R), and mental health status was assessed by the Depression, Anxiety and Stress Scale (DASS-21). Results: This study included 1210 respondents from 194 cities in China. In total, 53.8% of respondents rated the psychological impact of the outbreak as moderate or severe; 16.5% reported moderate to severe depressive symptoms; 28.8% reported moderate to severe anxiety symptoms; and 8.1% reported moderate to severe stress levels. Most respondents spent 20–24 h per day at home (84.7%); were worried about their family members contracting COVID-19 (75.2%); and were satisfied with the amount of health information available (75.1%). Female gender, student status, specific physical symptoms (e.g., myalgia, dizziness, coryza), and poor self-rated health status were significantly associated with a greater psychological impact of the outbreak and higher levels of stress, anxiety, and depression (p < 0.05). Specific up-to-date and accurate health information (e.g., treatment, local outbreak situation) and particular precautionary measures (e.g., hand hygiene, wearing a mask) were associated with a lower psychological impact of the outbreak and lower levels of stress, anxiety, and depression (p < 0.05). Conclusions: During the initial phase of the COVID-19 outbreak in China, more than half of the respondents rated the psychological impact as moderate-to-severe, and about one-third reported moderate-to-severe anxiety. Our findings identify factors associated with a lower level of psychological impact and better mental health status that can be used to formulate psychological interventions to improve the mental health of vulnerable groups during the COVID-19 epidemic.
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                Author and article information

                Journal
                Prog Neuropsychopharmacol Biol Psychiatry
                Prog Neuropsychopharmacol Biol Psychiatry
                Progress in Neuro-Psychopharmacology & Biological Psychiatry
                Published by Elsevier Inc.
                0278-5846
                1878-4216
                15 December 2020
                13 July 2021
                15 December 2020
                : 109
                : 110207
                Affiliations
                [a ]Department of Microbiology, Pediatrics, Radiology and Public Health, University of Zaragoza, Faculty of Medicine, Building A, 50009 Zaragoza, Spain
                [b ]Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Avenue Monforte de Lemos, 3-5, Pavilion 11, Floor 0, 28029 Madrid, Spain
                [c ]Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Avenue San Juan Bosco, 13, 50009 Zaragoza, Spain
                [d ]Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Medicine, Randwick 2052, Australia
                [e ]Psychiatry Service, Hospital Universitario Miguel Servet, Paseo Isabel la Católica, 1-3, 50009 Zaragoza, Spain
                [f ]Pharmacy Service. Hospital Universitario Miguel Servet, Paseo Isabel la Católica, 1-3, 50009 Zaragoza, Spain
                [g ]Department of Psychology and Sociology, Universidad de Zaragoza, Pedro Cerbuna, 12, 50009 Zaragoza, Spain
                Author notes
                [* ]Corresponding author.
                Article
                S0278-5846(20)30523-6 110207
                10.1016/j.pnpbp.2020.110207
                7834650
                33338558
                0a459c71-0836-4a32-a942-37e8c6a61fa2
                © 2020 Published by Elsevier Inc.

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

                History
                : 29 September 2020
                : 19 November 2020
                : 30 November 2020
                Categories
                Article

                anxiety,covid-19,prevalence,community-based studies,meta-analysis,covid-19, coronavirus infectious disease 2019,sars-cov-1, severe acute respiratory syndrome coronavirus 1,mers-cov, middle east respiratory syndrome coronavirus,gad, generalized anxiety disorder scale,dass, depression anxiety and stress scale,sas, zung self-rating anxiety scale,stai, state-trait anxiety inventory,bai, beck anxiety inventory,hads, anxiety and depression scale,bsi-53, brief symptom inventory-53

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