The role of the right prefrontal cortex in recognition of facial emotional expressions in depressed individuals: fNIRS study

Abstract

Depressed individuals often perceive neutral facial expressions as emotional. Neurobiological underpinnings of this effect remain unclear. We investigated the differences in prefrontal cortical (PFC) activation in depressed individuals vs. healthy controls (HC) during recognition of emotional and neutral facial expressions using functional near infrared spectroscopy (fNIRS). In Experiment 1, 33 depressed individuals and 20 HC performed the Emotion Intensity Rating task in which they rated intensity of facial emotional expressions. In Experiment 2, a different set of participants (18 depressed individuals and 16 HC) performed the same task while their PFC activation was measured using fNIRS. Both experiments showed that depressed individuals were slower and less accurate in recognizing neutral, but not happy or fearful, facial emotional expressions. Experiment 2 revealed that lower accuracy for neutral facial emotional expressions was associated with lower right PFC activation in depressed individuals, but not HC. In addition, depressed individuals, compared to HC, had lower right PFC activation during recognition of happy facial expressions. Relatively small sample size Recognition of neutral facial expressions is impaired in depressed individuals. Greater impairment corresponds to lower right PFC activation during neutral face processing. Recognition of happy facial expressions is comparable for depressed individuals and HC, but the former have significantly lower right PFC activation. Taken together, these findings suggest that the ability of depressed individuals to discriminate neutral and emotional signals in the environment may be affected by aberrant functioning of right PFC.