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      Metformin in Patients With Type 2 Diabetes and Kidney Disease : A Systematic Review

      1 , 1 , 2 , 3 , 4
      JAMA
      American Medical Association (AMA)

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          Abstract

          Metformin is widely viewed as the best initial pharmacological option to lower glucose concentrations in patients with type 2 diabetes mellitus. However, the drug is contraindicated in many individuals with impaired kidney function because of concerns of lactic acidosis.

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          Author and article information

          Journal
          JAMA
          JAMA
          American Medical Association (AMA)
          0098-7484
          December 24 2014
          December 24 2014
          : 312
          : 24
          : 2668
          Affiliations
          [1 ]Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut
          [2 ]Health Sciences Digital Library and Learning Center, University of Texas Southwestern Medical Center, Dallas
          [3 ]School of Life & Health Sciences, Aston University, Birmingham, United Kingdom
          [4 ]Division of Cardiology, University of Texas Southwestern Medical Center, Dallas
          Article
          10.1001/jama.2014.15298
          25536258
          050235e6-7977-498e-b72d-9a08ac5ccebe
          © 2014
          History

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