Contributors
Seonwook Kim: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
SoftwareRole: ValidationRole: VisualizationRole: Writing – review & editing
Lihua Yang: Role: Data curationRole: Formal analysisRole: MethodologyRole: SoftwareRole: ValidationRole:
VisualizationRole: Writing – review & editing
Seongu Kim: Role: Data curationRole: Formal analysisRole: MethodologyRole: SoftwareRole: ValidationRole:
VisualizationRole: Writing – review & editing
Richard G. Lee: Role: Resources
Mark J. Graham: Role: Resources
Judith A. Berliner: Role: ConceptualizationRole: InvestigationRole: ResourcesRole: Writing – review &
editing
Aldons J. Lusis: Role: ConceptualizationRole: InvestigationRole: Resources
Lei Cai: Role: MethodologyRole: Software
Ryan E. Temel: Role: ConceptualizationRole: Data curationRole: Writing – review & editing
Debra L. Rateri: Role: Data curationRole: MethodologyRole: Writing – review & editing
Sangderk Lee:
ORCID: http://orcid.org/0000-0001-8375-4606
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole:
SupervisionRole: ValidationRole: VisualizationRole: Writing – original draftRole:
Writing – review & editing
Christian Schulz: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
9
August
2017
Publication date Collection: 2017
Volume: 12
Issue: 8
Electronic Location Identifier: e0182566
Affiliations
[1
]
Saha Cardiovascular Research Center at the University of Kentucky College of Medicine,
Lexington, Kentucky, United States of America
[2
]
Cardiovascular Antisense Drug Discovery Group at the Ionis Pharmaceuticals, Inc.,
Carlsbad, California, United States of America
[3
]
Department of Medicine-Cardiology, University of California-Los Angeles School of
Medicine, Los Angeles, California, United States of America
[4
]
Department of Pharmacology & Nutritional Sciences at the University of Kentucky College
of Medicine, Lexington, Kentucky, United States of America
Ludwig-Maximilians-Universitat Munchen, GERMANY
Author notes
Competing Interests: Richard G. Lee and Mark J. Graham are employees of Ionis Pharmaceuticals. This does
not alter our adherence to PLOS ONE policies on sharing data and materials.
Author information
Article
Publisher ID:
PONE-D-17-11500
DOI: 10.1371/journal.pone.0182566
PMC ID: 5549937
PubMed ID: 28792970
SO-VID: 04369322-d4c6-4845-a31a-f80c674e51dc
Copyright © © 2017 Kim et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 23
March
2017
Date
accepted
: 20
July
2017
Page count
Figures: 4,
Tables: 0,
Pages: 18
Funding
Funded by: National Heart, Lung, and Blood Institute (US)
Award ID: R00HL105577
Award Recipient
:
ORCID: http://orcid.org/0000-0001-8375-4606
Sangderk Lee
Funded by: National Institute of General Medical Sciences (US)
Award ID: P20GM103527
Award Recipient
:
ORCID: http://orcid.org/0000-0001-8375-4606
Sangderk Lee
Funded by: National Heart, Lung, and Blood Institute (US)
Award ID: R01HL30568
Award Recipient
:
Aldons J. Lusis
Funded by: funder-id http://dx.doi.org/10.13039/100000050, National Heart, Lung, and Blood Institute;
Award ID: R01HL064731
Award Recipient
:
Judith A. Berliner
Funding sources were research grants of National Heart, Lung, and Blood Institute
(NHLBI, US) R00HL105577, R01HL030568, R01HL064731, and National Institute of General
Medical Sciences (NIGMS, US) P20GM103527. The Ionis Pharmaceuticals provided support
in the form of salaries for authors [RGL & MJG], but did not have any additional role
in the study design, data collection and analysis, decision to publish, or preparation
of the manuscript. The specific roles of these authors are articulated in the ‘author
contributions’ section.
Categories
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Vascular Medicine
Subject:
Vascular Diseases
Subject:
Aneurysms
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Lipids
Subject:
Cholesterol
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Lipids
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Blood Vessels
Subject:
Aorta
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Blood Vessels
Subject:
Aorta
Subject:
Biology and Life Sciences
Subject:
Nutrition
Subject:
Diet
Subject:
Medicine and Health Sciences
Subject:
Nutrition
Subject:
Diet
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Lipids
Subject:
Fats
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Heart
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Cardiovascular Anatomy
Subject:
Heart
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