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Disrupted-in-schizophrenia 1 protein aggregates in cerebrospinal fluid are elevated in patients with first-episode psychosis.
Marlene Pils
1
,
2 ,
Julia Rutsch
3 ,
Feride Eren
4 ,
Göran Engberg
4 ,
Fredrik Piehl
5
,
6 ,
Simon Cervenka
7
,
8 ,
Carl Sellgren
4
,
7 ,
Svenja Troßbach
3 ,
Dieter Willbold
1
,
2
,
9 ,
Sophie Erhardt
4 ,
Oliver Bannach
1
,
2 ,
Carsten Korth
3
Dec 2023
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Abstract
The disrupted-in-schizophrenia 1 (DISC1) protein is a key regulator at the intersection of major signaling pathways relevant for adaptive behavior. It is prone to posttranslational changes such as misassembly and aggregation but the significance of such transformations for human mental illness has remained unclear. We aimed to demonstrate the occurrence of DISC1 protein aggregates in patients with first-episode psychosis (FEP).