Obesity and mortality of COVID-19. Meta-analysis.

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Abstract

Obesity is a global disease with at least 2.8 million people dying each year as a result of being overweight or obese according to the world health organization figures. This paper aims to explore the links between obesity and mortality in COVID-19.

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Most cited references 31

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Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

David Moher, Alessandro Liberati, Jennifer Tetzlaff … (2009)

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Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy

Giacomo Grasselli, Alberto Zangrillo, Alberto Zanella … (2020)

In December 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) emerged in China and has spread globally, creating a pandemic. Information about the clinical characteristics of infected patients who require intensive care is limited.

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Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan

Xiaochen Li, Shuyun Xu, Muqing Yu … (2020)

Background In December 2019, COVID-19 outbreak occurred in Wuhan. Data on the clinical characteristics and outcomes of patients with severe COVID-19 are limited. Objective The severity on admission, complications, treatment, and outcomes of COVID-19 patients were evaluated. Methods Patients with COVID-19 admitted to Tongji Hospital from January 26, 2020 to February 5, 2020 were retrospectively enrolled and followed-up until March 3, 2020. Potential risk factors for severe COVID-19 were analyzed by a multivariable binary logistic model. Cox proportional hazard regression model was used for survival analysis in severe patients. Results We identified 269 (49.1%) of 548 patients as severe cases on admission. Elder age, underlying hypertension, high cytokine levels (IL-2R, IL-6, IL-10, and TNF-a), and high LDH level were significantly associated with severe COVID-19 on admission. The prevalence of asthma in COVID-19 patients was 0.9%, markedly lower than that in the adult population of Wuhan. The estimated mortality was 1.1% in nonsevere patients and 32.5% in severe cases during the average 32 days of follow-up period. Survival analysis revealed that male, elder age, leukocytosis, high LDH level, cardiac injury, hyperglycemia, and high-dose corticosteroid use were associated with death in patients with severe COVID-19. Conclusions Patients with elder age, hypertension, and high LDH level need careful observation and early intervention to prevent the potential development of severe COVID-19. Severe male patients with heart injury, hyperglycemia, and high-dose corticosteroid use may have high risk of death.

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Author and article information

Journal

Journal ID (iso-abbrev): Obes Res Clin Pract

Title: Obesity research & clinical practice

Publisher: Elsevier BV

ISSN: 1871-403X

ISSN (Print): 1871-403X

Publication date (Electronic): July 15 2020

Volume: 14

Issue: 4

Affiliations

[1 ] Doncaster and Bassetlaw Teaching Hospitals, Doncaster, UK, Honorary Lecturer at Sheffield University, Sheffield, UK. Electronic address: abdulzahra.hussain@nhs.net.

[2 ] Bariatric Unit, Department of General Surgery, Sunderland Royal Hospital, Sunderland, UK.

[3 ] Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei Province, China.

[4 ] The First Affiliated Hospital of Jinan University, 613 Huangpu Avenue West, Guangzhou, Guangdong Province, China.

[5 ] Bariatric Unit, Princess Royal University Hospital, King's College Hospitals NHS Foundation Trust, London, UK.

Article

Publisher Item ID: S1871-403X(20)30550-0

DOI: 10.1016/j.orcp.2020.07.002

PMC ID: 7346803

PubMed ID: 32660813

SO-VID: 2f95449f-eb34-4d7e-ab77-72c6757bb72e

History

Keywords: Body mass index,COVID-19,Intensive care unit,Mortality,Obesity,Total body weight,World Health Organization

Data availability:

Keywords: Body mass index, COVID-19, Intensive care unit, Mortality, Obesity, Total body weight, World Health Organization

Obesity and mortality of COVID-19. Meta-analysis.

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Abstract

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Novel Coronavirus Disease COVID-19

Most cited references 31

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy

Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan

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