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      ModelFinder: fast model selection for accurate phylogenetic estimates.

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          Abstract

          Model-based molecular phylogenetics plays an important role in comparisons of genomic data, and model selection is a key step in all such analyses. We present ModelFinder, a fast model-selection method that greatly improves the accuracy of phylogenetic estimates by incorporating a model of rate heterogeneity across sites not previously considered in this context and by allowing concurrent searches of model space and tree space.

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          Most cited references30

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          ProtTest: selection of best-fit models of protein evolution.

          Using an appropriate model of amino acid replacement is very important for the study of protein evolution and phylogenetic inference. We have built a tool for the selection of the best-fit model of evolution, among a set of candidate models, for a given protein sequence alignment. ProtTest is available under the GNU license from http://darwin.uvigo.es
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            Comparison of phylogenetic trees

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              Bayes Factors

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                Author and article information

                Journal
                Nat Methods
                Nature methods
                Springer Science and Business Media LLC
                1548-7105
                1548-7091
                Jun 2017
                : 14
                : 6
                Affiliations
                [1 ] Land &Water, CSIRO, Canberra, Australian Capital Territory, Australia.
                [2 ] Faculty of Pharmacy &Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
                [3 ] Center for Integrative Bioinformatics Vienna, Max F. Perutz Laboratories, University of Vienna &Medical University of Vienna, Vienna, Austria.
                [4 ] Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia.
                [5 ] Bioinformatics and Computational Biology, Faculty of Computational Science, University of Vienna, Vienna, Austria.
                Article
                nmeth.4285 EMS72237
                10.1038/nmeth.4285
                5453245
                28481363
                723ac4a2-fd20-4049-9634-b385f1de3473
                History

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