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      Ergebnisse der Inneren Medizin und Kinderheilkunde 

      Klinik und Pathophysiologie des Karzinoids und Karzinoidsyndroms unter besonderer Berücksichtigung der Pharmakologie des 5-Hydroxytryptamins

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      Springer Berlin Heidelberg

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          Isolation of melatonin and 5-methoxyindole-3-acetic acid from bovine pineal glands.

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            On the presence of 3-hydroxytyramine in brain.

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              Enzymatic O-methylation of N-acetylserotonin to melatonin.

              An enzyme, hydroxyindole-O-methyl transferase, that can transfer the methyl group of S-adenosylmethionine to the hydroxy group of N-acetylserotonin to form the hormone melatonin is described. This enzyme, which is highly localized in the pineal gland, also O-methylates serotonin.
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                1961
                : 292-559
                10.1007/978-3-642-94808-4_7
                c1c1c304-9b75-4ba3-9549-c0bb7ded02fb
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