Journal: Lifestyle Genomics
Submission Deadline: January 31, 2025
It is now well recognized that genetic variants (i.e. single nucleotide polymorphisms and copy number variants) can influence a person’s response to specific nutrients or dietary patterns. Some genetic variants have been associated with inter-individual differences in the digestion, absorption, and metabolism of a nutrient, while other variants have been more broadly associated with disease biomarkers and health outcomes. While these variants have garnered considerable interest for those working in the field of precision nutrition, there remain significant gaps in our understanding of the underlying molecular mechanisms by which these variants influence outcomes. For example, some variants can influence gene expression through transcriptional and epigenetic mechanisms, while others can influence protein function. The use of cell culture and animal models, therefore, provides opportunities to explore the mechanisms and pathways influenced by genetic variants that are not always feasible to study directly in humans. Moreover, these model systems are also widely used to advance understanding of the broad impact of nutrients and diets on global gene expression (transcriptomics), methylation patterns (epigenetics), protein abundance (proteomics) and metabolites (metabolomics) in individual cell types and tissues.
The overarching goal of this collection of articles is to demonstrate how preclinical investigations can help advance our understanding of the molecular mechanisms through which individual nutrients and dietary patterns affect health and disease outcomes. This collection will consider in vitro (in both animal and human cells) and in vivo animal studies, but not human clinical trials. In this Special Call, we welcome original research, review articles, and perspectives related to the use and value of preclinical investigations that provide new mechanistic knowledge and insight regarding diet-gene interactions.
If you have any questions about this Special Call or would like to confirm the suitability of your manuscript, please email David M. Mutch (Editor-in-Chief of Lifestyle Genomics).
Please select the option “Call for Papers: Preclinical Investigations to Advance Understanding of Nutrigenetic and Nutrigenomic Targets” when submitting your manuscript and mention this Call for Papers in your cover letter.
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