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      HIV testing strategies outside of health care settings in the European Union (EU)/European Economic Area (EEA): a systematic review to inform European Centre for Disease Prevention and Control guidance

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          Abstract

          Objectives

          In recent years, new technologies and new approaches to scale up HIV testing have emerged. The objective of this paper was to synthesize the body of recent evidence on strategies aimed at increasing the uptake and coverage of HIV testing outside of health care settings in the European Union (EU)/European Economic Area (EEA).

          Methods

          Systematic searches to identify studies describing effective HIV testing interventions and barriers to testing were run in five databases (2010–2017) with no language restrictions; the grey literature was searched for similar unpublished studies (2014–2017). Study selection, data extraction and critical appraisal were performed by two independent reviewers following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines.

          Results

          Eighty studies on HIV testing in non‐health care settings were identified, the majority set in Northern Europe. Testing was implemented in 65 studies, with men who have sex with men the risk group most often targeted. Testing coverage and positivity/reactivity rates varied widely by setting and population group. However, testing in community and outreach settings was effective at reaching people who had never previously been tested and acceptability of HIV testing, particularly rapid testing, outside of health care settings was found to be high. Other interventions aimed to increase HIV testing identified were: campaigns ( n = 8), communication technologies ( n = 2), education ( n = 3) and community networking ( n = 1).

          Conclusions

          This review has identified several strategies with potential to achieve high HIV testing coverage outside of health care settings. However, the geographical spread of studies was limited, and few intervention studies reported before and after data, making it difficult to evaluate the impact of interventions on test coverage.

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          Most cited references62

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          The CD4:CD8 ratio is associated with markers of age-associated disease in virally suppressed HIV-infected patients with immunological recovery.

          Inversion of the CD4:CD8 ratio ( 350 cells/μL and age 200 cells/μL and those with CD4 counts > 500 cells/μL. The CD4:CD8 ratio in treated HIV-infected subjects with good immunovirological response is independently associated with markers of age-associated disease. Hence, it might be a clinically useful predictor of non-AIDS-defining conditions. © 2013 British HIV Association.
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            HIV testing in community settings in resource-rich countries: a systematic review of the evidence.

            Community HIV testing represents an opportunity for diagnosing HIV infection among individuals who may not have contact with health services, especially in hard-to-reach groups. The aim of this review was to assess the evidence for feasibility, acceptability and effectiveness of HIV testing strategies in community settings in resource-rich countries. The PubMed database was searched for English language studies of outreach HIV testing in resource-rich countries. Studies were included if they reported one of the following outcome measures: uptake of testing; seropositivity; client acceptability; or provider acceptability. Forty-four studies were identified; the majority took place in the USA and targeted men who have sex with men. Uptake of HIV testing varied between 9 and 95% (in 14 studies). Seropositivity was ≥ 1% in 30 of 34 studies. In 16 studies the proportion of patients who received their test results varied from 29 to 100% and rapid testing resulted in a higher proportion of clients receiving their results. Overall, client satisfaction with community HIV testing was high. However, concern remained over confidentiality, professional standards and the need for post-test counselling. Staff reported positive attitudes towards community testing. In the majority of studies, the reported seropositivity was higher than 1/1000, the threshold deemed to be cost-effective for routinely offering testing. Rapid testing improved the return of HIV test results to clients. HIV testing in outreach settings may be important in identifying undiagnosed infections in at-risk populations, but appropriate data to evaluate these initiatives must be collected. © 2012 British HIV Association.
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              Design and baseline findings of a large-scale rapid response to an HIV outbreak in people who inject drugs in Athens, Greece: the ARISTOTLE programme.

              To (i) describe an intervention implemented in response to the HIV-1 outbreak among people who inject drugs (PWIDs) in Greece (ARISTOTLE programme), (ii) assess its success in identifying and testing this population and (iii) describe socio-demographic characteristics, risk behaviours and access to treatment/prevention, estimate HIV prevalence and identify risk factors, as assessed at the first participation of PWIDs.
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                Author and article information

                Contributors
                sara.croxford@phe.gov.uk
                Journal
                HIV Med
                HIV Med
                10.1111/(ISSN)1468-1293
                HIV
                HIV Medicine
                John Wiley and Sons Inc. (Hoboken )
                1464-2662
                1468-1293
                04 November 2019
                March 2020
                : 21
                : 3 ( doiID: 10.1111/hiv.v21.3 )
                : 142-162
                Affiliations
                [ 1 ] National Infection Service Public Health England London UK
                [ 2 ] European Centre for Disease Prevention and Control Stockholm Sweden
                [ 3 ] University of Pisa Pisa Italy
                [ 4 ] Directorate of HIV and Sexual Health Chelsea and Westminster Hospital NHS Foundation Trust London UK
                [ 5 ] CHIP Rigshospitalet ‐ University of Copenhagen Copenhagen Denmark
                Author notes
                [*] [* ] Correspondence: Senior HIV Scientist, Sara Croxford, Centre for Infectious Disease Surveillance and Control, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK. Tel: +44 0 20 83277406; fax: +44 0 20 83276230; e‐mail: sara.croxford@ 123456phe.gov.uk

                Author information
                https://orcid.org/0000-0003-2220-623X
                https://orcid.org/0000-0002-2217-4664
                https://orcid.org/0000-0002-2586-0248
                https://orcid.org/0000-0003-0185-7359
                Article
                HIV12807
                10.1111/hiv.12807
                7065225
                31682060
                d5960c70-5b9f-4c35-a452-58d0d0518213
                © 2019 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

                History
                : 20 March 2019
                : 05 September 2019
                : 16 September 2019
                Page count
                Figures: 1, Tables: 3, Pages: 21, Words: 15455
                Funding
                Funded by: European Centre for Disease Prevention and Control , open-funder-registry 10.13039/501100000805;
                Award ID: ECDC/2016/035
                Categories
                Original Research
                Original Research
                Custom metadata
                2.0
                March 2020
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.7.7 mode:remove_FC converted:11.03.2020

                Infectious disease & Microbiology
                hiv,systematic review,europe,hiv testing,adults
                Infectious disease & Microbiology
                hiv, systematic review, europe, hiv testing, adults

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